Polymorphisms in the two helicases ERCC2/XPD and ERCC3/XPB of the transcription factor IIH complex and risk of lung cancer: a case-control analysis in a Chinese population.

doi:10.1158/1055-9965.EPI-06-0194

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Polymorphisms in the two helicases ERCC2/XPD and ERCC3/XPB of the transcription factor IIH complex and risk of lung cancer: a case-control analysis in a Chinese population.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2006

Hu Zhibin, Xu Liang, Shao Minhua, Yuan Jing, Wang Yi, Wang Feng, Yuan Wentao, Qian Ji, Ma Hongxia, Wang Ying, Liu Hongliang, Chen Weihong, Yang Lin, Jing Guangfu, Huo Xiang, Chen Feng, Jin Li, Wei Qingyi, Wu Tangchun, Lu Daru, Huang Wei, Shen Hongbing

Abstract excerpt

The transcription factor IIH (TFIIH) helicases ERCC2/XPD and ERCC3/XPB are responsible for opening the DNA strand around the lesion site during nucleotide excision repair process. Genetic variants in these two genes may be markers for interindividual variability in DNA repair capacity and thus predisposition to cancer risk. In this case-control study of 1,010 incident lung cancer cases and 1,011 age and sex...

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Identifiers

PMID: 16835333
DOI: 10.1158/1055-9965.EPI-06-0194

Genes

ERCC2
ERCC3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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