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Article

Accumulation of Promoter Methylation Suggests Epigenetic Progression in Squamous Cell Carcinoma of the Esophagus

1 Aug 2006

Abstract excerpt

PURPOSE: Squamous esophageal cancer is common in non-Western countries and has a well-defined progression of preinvasive dysplasia leading to invasive squamous cell carcinoma. We examined the changes in promoter region methylation occurring during neoplastic progression. EXPERIMENTAL DESIGN: The frequency of epigenetic changes in the promoter region of 14 genes epigenetically silenced in other cancers was...

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PMID: 16899597
DOI: 10.1158/1078-0432.ccr-05-2858

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