Article
Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers.
Carcinogenesis - 1 Jul 2009
Tessema Mathewos, Yu Yang Y, Stidley Christine A, Machida Emi O, Schuebel Kornel E, Baylin Stephen B, Belinsky Steven A
Abstract excerpt
Aberrant promoter hypermethylation is one of the major mechanisms in carcinogenesis and some critical growth regulatory genes have shown commonality in methylation across solid tumors. Twenty-six genes, 14 identified through methylation in colon and breast cancers, were evaluated using primary lu...
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