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Detection of Promoter Hypermethylation of Multiple Genes in the Tumor and Bronchoalveolar Lavage of Patients with Lung Cancer

1 Apr 2004

Abstract excerpt

PURPOSE: Aberrant promoter hypermethylation of several known or putative tumor suppressor genes occurs frequently during the pathogenesis of lung cancers and is a promising marker for cancer detection. We investigated the feasibility of detecting aberrant DNA methylation in the bronchoalveolar lavage (BAL) samples of lung cancer patients. EXPERIMENTAL DESIGN: We examined the tumor and the matched BAL DNA for...

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PMID: 15073103
DOI: 10.1158/1078-0432.ccr-1111-3

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