Targeting ALK: a promising strategy for the treatment of non-small cell lung cancer, non-Hodgkin's lymphoma, and neuroblastoma.

doi:10.1007/s11523-012-0227-8

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Article

Targeting ALK: a promising strategy for the treatment of non-small cell lung cancer, non-Hodgkin's lymphoma, and neuroblastoma.

Targeted oncology - 1 Sept 2012

Morales La Madrid Andres, La Madrid Andres Morales, Campbell Nicholas, Smith Sonali, Cohn Susan L, Salgia Ravi

Abstract excerpt

Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor that affects a number of biological and biochemical functions through normal ligand-dependent signaling. It has oncogenic functions in a number of tumors including non-small cell lung cancer (NSCLC), anaplastic large cell lymphoma, and neuroblastoma when altered by translocation or amplification or mutation. On August 2011, a small molecule inhibitor...

Topics

Anaplastic Lymphoma Kinase
Antineoplastic Agents
Carcinoma, Non-Small-Cell Lung
Clinical Trials as Topic
Crizotinib
Drug Resistance, Neoplasm
Gene Expression Regulation, Neoplastic
Humans
Lung Neoplasms
Lymphoma, Non-Hodgkin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Genetic

Mutation

Neuroblastoma

Oncogene Proteins, Fusion

Pyrazoles

Pyridines

Receptor Protein-Tyrosine Kinases

Signal Transduction

Source

Open in PubMed

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PMID: 22968692
DOI: 10.1007/s11523-012-0227-8

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