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Article

ALK alterations and inhibition in lung cancer.

Seminars in cancer biology - 1 Feb 2017

Le Tri, Gerber David E

Abstract excerpt

The advent of precision medicine in non-small cell lung cancer has remarkably altered the direction of research and improved clinical outcomes. The identification of molecular subsets with differential response to targeted therapies began with the identification of epidermal growth factor receptor mutated tumors in subsets of non-small cell lung cancer (NSCLC). Emboldened by unprecedented response rates to kinase...

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Topics

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Share to Anaplastic Lymphoma Kinase
Share to Carcinoma, Non-Small-Cell Lung
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ErbB Receptors

Share to ALK gene

Share to Molecular Targeted Therapy

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Share to Receptor Protein-Tyrosine Kinases

Source

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Identifiers

PMID: 27637426
DOI: 10.1016/j.semcancer.2016.08.007
PMCID: PMC5316306

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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