Article
CTLA-4 +49 A/G genotype and HLA-DRB1 polymorphisms in Turkish patients with Henoch-Schönlein purpura.
Pediatric nephrology (Berlin, Germany) - 1 Aug 2008
Soylemezoglu Oguz, Peru Harun, Gonen Sevim, Cetinyurek Aysun, Ozkaya Ozan, Bakkaloğlu Sevcan, Buyan Necla, Hasanoglu Enver
Abstract excerpt
The pathogenesis of Henoch-Schönlein purpura (HSP) remains unknown; however, it is generally considered to be an immune complex-mediated disease. Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) is expressed on activated T cells, and, thus, it is critically involved in the immune response. We aimed to investigate the possible influence of CTLA-4 polymorphisms for susceptibility to HSP and determine if there...
Topics
- Antigens, CD
- CTLA-4 Antigen
- Child
- Child, Preschool
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- IgA Vasculitis
- Male
- Polymorphism, Genetic