Article
Association of CTLA-4 exon 1(+49 A/G) polymorphism and susceptibility to SLE in Egyptian children and adolescents.
Lupus - 1 Mar 2026
Arab Faika, Saleh Sarah A, Ibrahim Dina M, Barakat Amany N, Yousef Aly A, Abdulhay Mohamed, Haridi Mohammed K, Al-Fahham Marwa M, Selim Dalia M, Ismail Ahmed H, Younis Mohammed M S, Soliman Attia A, Shehata Hassan, Ashraf Bassem, Nabil Rehab M, Abdelnaser Mostafa M, AbdelKareem Mohammed Z, Afify Mona R, Bakhsh Wesam K, Alkashgari Hossam R, Almoraie Laila M, Shalabi Maher S, Khazindar Abdullah R, Bawazir Yasser, Mustafa Mohammad, Daghistani Yassir, Alomari Reem A, Balkhair Abrar A, Alhusaini Wejdan Ibrahim, Abdel Raouf Batoul M, Elmikaty Hani A, Taha Sherif, El-Gaaly Sonya A A, Ayad Ayman S A M, Abdalla Hytham, Sayed Mohamed Elwan, Shoaeir Mohamed Z, Abass Awad S, Abdel-Aziz Tarek M, Emam Ahmed A
Abstract excerpt
BackgroundRecently, Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) gene has emerged as an attractive candidate gene implicated in susceptibility to autoimmune disease such as Juvenile-onset SLE (JSLE).ObjectiveTo investigate CTLA-4 exon 1 + 49A/G (rs231775) SNP as a genetic marker for susceptibility to JSLE and lupus nephritis in Egyptian children and adolescents.MethodsThis prospective case-control study...
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