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Article

CTLA-4 exon 1 +49A/G polymorphism is associated with renal involvement in pediatric Henoch-Schönlein purpura.

Pediatric nephrology (Berlin, Germany) - 1 Nov 2012

Wang Jian-Jun, Shi Yan-Ping, Yue Huang, Chun Wu, Zou Li-Ping

Abstract excerpt

BACKGROUND: Henoch-Schönlein purpura (HSP) is a multisystemic vasculitis of unknown etiology. Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and CD28 have been reported to be important candidate genes for conferring susceptibility to autoimmunity. In this study, we investigated the correlation of CTLA-4 and CD28 gene polymorphisms with HSP in children with and without renal involvement. METHODS: The CTLA-4...

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PMID: 22700162
DOI: 10.1007/s00467-012-2216-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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