Article
Interleukin promoter polymorphisms and prognosis in colorectal cancer.
Carcinogenesis - 1 Jun 2008
Wilkening Stefan, Tavelin Björn, Canzian Federico, Enquist Kerstin, Palmqvist Richard, Altieri Andrea, Hallmans Göran, Hemminki Kari, Lenner Per, Försti Asta
Abstract excerpt
There is strong evidence that cancer-associated inflammation promotes tumor growth and progression. This is especially true for colorectal cancer (CRC). Interleukins (ILs) are important modulators for inflammation. We examined whether promoter polymorphisms in key IL genes (IL4, IL4R, IL6, IL8 and IL10) are associated with the risk or clinical outcome of CRC. Five single-nucleotide polymorphisms (SNPs) were...
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