Article
Impact of interleukin-10 gene polymorphisms on survival in patients with colorectal cancer.
Journal of Korean medical science - 1 Sept 2013
Ting Wen-Chien, Chen Lu-Min, Huang Li-Chia, Hour Mann-Jen, Lan Yu-Hsuan, Lee Hong-Zin, You Bang-Jau, Chang Ta-Yuan, Bao Bo-Ying
Abstract excerpt
Chronic inflammation is thought to be the leading cause of colorectal cancer, and interleukin-10 (IL10) has been identified as a potent immunomodulatory cytokine that regulates inflammatory responses in the gastrointestinal tract. Although several single nucleotide polymorphisms (SNPs) in IL10 have been associated with the risk of colorectal cancer, their prognostic significance has not been determined. Two...
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