Article
The molecular mechanism of hepcidin-mediated ferroportin down-regulation.
Molecular biology of the cell - 1 Jul 2007
De Domenico Ivana, Ward Diane McVey, Langelier Charles, Vaughn Michael B, Nemeth Elizabeta, Sundquist Wesley I, Ganz Tomas, Musci Giovanni, Kaplan Jerry
Abstract excerpt
Ferroportin (Fpn) is the only known iron exporter in vertebrates. Hepcidin, a peptide secreted by the liver in response to iron or inflammation, binds to Fpn, inducing its internalization and degradation. We show that after binding of hepcidin, Fpn is tyrosine phosphorylated at the plasma membran...
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