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Article

Role of matriptase-2 (TMPRSS6) in iron metabolism.

Acta haematologica - 1 Jan 2009

Lee Pauline

Abstract excerpt

Iron, an essential element for life, is regulated primarily at the level of uptake, storage, and transport in order to maintain sufficient availability for normal physiology. The key protein in iron homeostasis is a 25-amino-acid peptide, hepcidin, which modulates the amount of iron in the circulation by binding and promoting the degradation of the iron exporter ferroportin. Given the central importance of...

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Share to Anemia, Iron-Deficiency
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Proteins

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Source

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Identifiers

PMID: 19907145
DOI: 10.1159/000243792
PMCID: PMC2855275

Genes

TMPRSS6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Role of matriptase-2 (TMPRSS6) in iron metabolism.PMID 19907145Read ↗

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Iron refractory iron deficiency anemia.Semantic proximity Read ↗

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Effect of Erythropoietin, Iron Deficiency and Iron Overload on Liver Matriptase-2 (TMPRSS6) Protein Content in Mice and Rats.Semantic proximity Read ↗

Functional analysis of matriptase-2 mutations and domains: insights into the molecular basis of iron-refractory iron deficiency anemia.Semantic proximity Read ↗

TMPRSS6 Gene Polymorphism and Serum Hepcidin in Iron Deficiency AnemiaSemantic proximity Read ↗

A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron.Semantic proximity Read ↗

Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression.Semantic proximity Read ↗

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