Article
No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver disease.
Alcoholism, clinical and experimental research - 1 Jun 2008
Stickel Felix, Osterreicher Christoph H, Halangk Juliane, Berg Thomas, Homann Nils, Hellerbrand Claus, Patsenker Eleonora, Schneider Vreni, Kolb Armin, Friess Helmut, Schuppan Detlef, Puhl Gero, Seitz Helmut K, Leathart Julian L B, Day Christopher P
Abstract excerpt
BACKGROUND: As only a minority of alcoholics develop cirrhosis, polymorphic genes, whose products are involved in fibrosis development were suggested to confer individual susceptibility. We tested whether a functional promoter polymorphism in the gene encoding matrix metalloproteinase-3 (MMP-3; 1171 5A/6A) was associated liver cirrhosis in alcoholics. METHODS: Independent cohorts from the UK and Germany were...
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