Article
The association of MMP-1, -3 and -9 genotypes with the prognosis of HCV-related hepatocellular carcinoma patients.
Research communications in molecular pathology and pharmacology - 1 Jan 2005
Okamoto Kinya, Mandai Mari, Mimura Kenichi, Murawaki Yoshikazu, Yuasa Isao
Abstract excerpt
BACKGROUND/AIMS: Matrix metalloproteinases (MMPs) play important roles in cancer invasion and metastasis. Recently, functional gene polymorphisms in the promoter regions of MMP-1 1G/2G, MMP-3 5A/6A and MMP-9 C/T have been found, and have been reported to be associated with the prognosis of various cancers. In this study, we examined the association of the MMP-1, -3, -9 genotypes with the prognosis of...
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