Article
Prognostic significance of MMP-1 and MMP-3 functional promoter polymorphisms in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2005
Zinzindohoué Franck, Lecomte Thierry, Ferraz Jean-Marc, Houllier Anne-Marie, Cugnenc Paul-Henri, Berger Anne, Blons Hélène, Laurent-Puig Pierre
Abstract excerpt
PURPOSE: Matrix metalloproteinase (MMP) belongs to a large group of proteases capable of breaking essentially all components of the extracellular matrix. They are implicated in all steps of tumorogenesis, cancer invasion, and metastasis. Among them, metalloproteinase type 1 (MMP-1) is implicated in tumor invasion and metastasis in different types of cancers including colorectal cancer in which its expression was...
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