Homozygosity for rs738409:G in PNPLA3 is associated with increased mortality following an episode of severe alcoholic hepatitis.

doi:10.1016/j.jhep.2017.01.018

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Article

Homozygosity for rs738409:G in PNPLA3 is associated with increased mortality following an episode of severe alcoholic hepatitis.

Journal of hepatology - 1 Jul 2017

Atkinson Stephen R, Way Michael J, McQuillin Andrew, Morgan Marsha Y, Thursz Mark R

Abstract excerpt

BACKGROUND & AIMS: Carriage of rs738409:G in PNPLA3 is associated with an increased risk of developing alcohol-related cirrhosis and has a significant negative effect on survival. Short-term mortality in patients with severe alcoholic hepatitis is high; drinking behaviour is a major determinant of outcome in survivors. The aim of this study was to determine whether carriage of rs738409:G has an additional...

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PMID: 28161471
DOI: 10.1016/j.jhep.2017.01.018

Genes

PNPLA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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