Article
The influence of fruit and vegetable consumption and genetic variation on NAD(P)H:quinone oxidoreductase (NQO1) phenotype in an endoscopy-based population.
Nutrition and cancer - 1 Jan 2008
Tijhuis Mariken J, Boerboom Anne-Marie J F, Visker Marleen H P W, Op den Camp Liesbeth, Nagengast Fokko M, Tan Adriaan C I T L, Rietjens Ivonne M C M, Kok Frans J, Aarts Jac M M J G, Kampman Ellen
Abstract excerpt
NAD(P)H:quinone oxidoreductase (NQO1) is an inducible detoxification enzyme relevant for colorectal cancer biochemoprevention. We evaluated the influence of recent fruit and vegetable (F&V) consumption and polymorphisms in NQO1 and transcription factor NFE2L2 on rectal NQO1 phenotype and also whether white blood cell (WBC) NQO1 activity reflects rectal activity. Among 94 sigmoidoscopy patients, we assessed F&V...
Topics
- Adult
- Aged
- Colorectal Neoplasms
- Enzyme Activation
- Female
- Fruit
- Genetic Variation
- Genotype
- Humans
- Life Style