NQO1 and NFE2L2 polymorphisms, fruit and vegetable intake and smoking and the risk of colorectal adenomas in an endoscopy-based population.

doi:10.1002/ijc.23246

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Article

NQO1 and NFE2L2 polymorphisms, fruit and vegetable intake and smoking and the risk of colorectal adenomas in an endoscopy-based population.

International journal of cancer - 15 Apr 2008

Tijhuis Mariken J, Visker Marleen H P W, Aarts Jac M M J G, Laan Wijnand, de Boer Sybrand Y, Kok Frans J, Kampman Ellen

Abstract excerpt

Both environment and genetics contribute to the pathogenesis and prevention of colorectal neoplasia. NAD(P)H: quinone oxidoreductase (NQO1) is a detoxification enzyme that is polymorphic and inducible. We investigated interactions between lifestyle factors and polymorphisms in NQO1 and its key regulatory transcription factor NFE2L2 in colorectal adenoma risk. The NQO1 c.609C>T and g.-718A>G and NFE2L2 g.-650C>A,...

Topics

Adenoma
Adult
Aged
Case-Control Studies
Colonoscopy
Colorectal Neoplasms
Feeding Behavior
Female
Fruit
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Life Style

Male

Middle Aged

NAD(P)H Dehydrogenase (Quinone)

NF-E2-Related Factor 2

Netherlands

Nutrition Surveys

Source

Open in PubMed

Identifiers

PMID: 18074351
DOI: 10.1002/ijc.23246

Genes

NQO1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18074351-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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