Article
Glutathione S-transferase phenotypes in relation to genetic variation and fruit and vegetable consumption in an endoscopy-based population.
Carcinogenesis - 1 Apr 2007
Tijhuis Mariken J, Visker Marleen H P W, Aarts Jac M M J G, Peters Wilbert H M, Roelofs Hennie M J, den Camp Liesbeth Op, Rietjens Ivonne M C M, Boerboom Anne-Marie J F, Nagengast Fokko M, Kok Frans J, Kampman Ellen
Abstract excerpt
High glutathione S-transferase (GST) activity may contribute to colorectal cancer prevention. Functional polymorphisms are known in the GSTM1, GSTT1, GSTA1 and GSTP1 genes. The influence of these GST polymorphisms and recent fruit and vegetable consumption on GST levels and activity has not been investigated simultaneously in a human population. Also, it is not clear if blood GST activity reflects rectal GST...
Topics
- Adolescent
- Adult
- Aged
- Biomarkers, Tumor
- Colorectal Neoplasms
- Eating
- Endoscopy
- Female
- Fruit
- Genetic Variation
- Glutathione S-Transferase pi
- Glutathione Transferase
- Humans