Article
A NAD(P)H:quinone oxidoreductase 1 polymorphism is a risk factor for human colon cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2006
Begleiter Asher, Hewitt Donna, Maksymiuk Andrew W, Ross David A, Bird Ranjana P
Abstract excerpt
Colon cancer is one of the most common cancers in North America and generally develops from colonic epithelial cells following initiation by carcinogens. We have shown that the phase II detoxifying enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1) contributes to the inhibition of carcinogen-induced...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alcohol Drinking
- Canada
- Case-Control Studies
- Colonic Neoplasms
- Female
- Genotype
- Humans
- Male
- Middle Aged
- NAD(P)H Dehydrogenase (Quinone)
- Polymorphism, Genetic
- Risk Factors
- Smoking