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Article

A NAD(P)H:quinone oxidoreductase 1 polymorphism is a risk factor for human colon cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2006

Begleiter Asher, Hewitt Donna, Maksymiuk Andrew W, Ross David A, Bird Ranjana P

Abstract excerpt

Colon cancer is one of the most common cancers in North America and generally develops from colonic epithelial cells following initiation by carcinogens. We have shown that the phase II detoxifying enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1) contributes to the inhibition of carcinogen-induced colon cancer in rats at both the initiation and postinitiation stages. An inactivating polymorphism at base 609 of the...

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Identifiers

PMID: 17164365
DOI: 10.1158/1055-9965.EPI-06-0661

Genes

NQO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A NAD(P)H:quinone oxidoreductase 1 polymorphism is a risk factor for human colon cancer.PMID 17164365Read ↗

NAD(P)H quinone oxidoreductase 1 codon 609 polymorphism and its association to colorectal cancer.Semantic proximity Read ↗

Genetic polymorphism 609C>T in NAD(P)H:quinone oxidoreductase 1 enhances the risk of proximal colon cancer.Semantic proximity Read ↗

Role of NADPH Quinone Reductase 1 (NQO1) Polymorphism in Prevention, Diagnosis, and Treatment of Gastrointestinal Cancers.Semantic proximity Read ↗

NQO1 609C>T polymorphism interaction with tobacco smoking and alcohol drinking increases colorectal cancer risk in a Chinese population.Semantic proximity Read ↗

Association between NQO1 C609T polymorphism and colorectal cancer risk.Semantic proximity Read ↗

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Association of NQO1 rs1800566 polymorphism and the risk of colorectal cancer: a meta-analysis.Semantic proximity Read ↗

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