Article
Three new regions on chromosome 17p13.3 distal to p53 with possible tumor suppressor gene involvement in lung cancer.
Japanese journal of cancer research : Gann - 1 Jun 2000
Tsuchiya E, Tanigami A, Ishikawa Y, Nishida K, Hayashi M, Tokuchi Y, Hashimoto T, Okumura S, Tsuchiya S, Nakagawa K
Abstract excerpt
We investigated loss of heterozygosity (LOH) at the distal portion of the p53 gene on the short arm of chromosome 17 in lung cancers in order to search for new tumor suppressor genes. The roles of the putative genes were also studied in terms of pathological features. One hundred and forty-five resected non-small cell lung cancers were examined for LOH using 11 markers mapped on, and distal to the p53 locus, and...
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