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Article

Sensitive detection of EGFR mutations using a competitive probe to suppress background in the SMart Amplification Process.

Biologicals : journal of the International Association of Biological Standardization - 1 Jul 2008

Kawai Yuki, Kikuchi Takeshi, Mitani Yasumasa, Kogo Yasushi, Itoh Masayoshi, Usui Kengo, Kanamori Hajime, Kaiho Ai, Takakura Hideki, Hoshi Kanako, Cizdziel Paul E, Hayashizaki Yoshihide

Abstract excerpt

In a previous study, a single nucleotide polymorphism (SNP) diagnostic system named the SMart Amplification Process version 2 (SMAP 2) was reported, which enabled rapid gene diagnostics from crude samples such as whole blood. The asymmetric primer design and use of Taq MutS were reported as innovative background suppression technologies employed by SMAP 2, but Taq MutS is known to display differential affinities...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18440823
DOI: 10.1016/j.biologicals.2008.01.003

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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