Article
Developing the use of mismatch binding proteins for discovering rare somatic mutations.
Molecular and cellular probes - 1 Jun 2005
Baum Larry, Ng Alex, Leung Wai Keung
Abstract excerpt
A method for detecting rare, unknown, somatic mutations could allow presymptomatic cancer screening from human fluids. Immobilized mismatch binding protein can bind DNA heteroduplexes while allowing homoduplexes to be washed away, thus enriching for rare mutations. We examined the potential use, for mutation enrichment, of a fusion protein of maltose binding protein and the mismatch binding protein TaqMutS...
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