Article
A cost effective base-matching assay with low backgrounds.
Nucleic acids research - 15 Nov 1996
Su X, Mushinsky G, Comeau A M
Abstract excerpt
Base-matching or so-called mini-sequencing is a powerful technique for genotyping and mutation identification. However, its application is often hampered by high background and high cost. We have decreased the background by approximately 5-fold by incorporating an end-blocking step and using only 1/10 of the usual nucleotide concentrations.
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