Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil.

doi:10.1016/j.jaci.2012.10.043

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Article

Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil.

The Journal of allergy and clinical immunology - 1 Jun 2013

Figueiredo Camila Alexandrina, Barreto Maurício Lima, Alcantara-Neves Neuza Maria, Rodrigues Laura Cunha, Cooper Philip John, Cruz Alvaro A, Pontes-de-Carvalho Lain Carlos, Lemaire Denise C, dos Santos Costa Ryan, Amorim Leila D, Vergara Candelaria, Rafaels Nicholas, Gao Li, Foster Cassandra, Campbell Monica, Mathias Rasika A, Barnes Kathleen C

Abstract excerpt

BACKGROUND: Helminth infections are associated with protection against allergies. It is postulated that IL-10 production after helminth infection suppresses skin hypersensitivity and increases IgG₄ production, protecting against allergies. OBJECTIVE: We aimed to determine whether IL10 polymorphisms are associated with helminth infection and the risk of wheeze and allergy. METHODS: Twelve IL10 single nucleotide...

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PMID: 23273955
DOI: 10.1016/j.jaci.2012.10.043
PMCID: PMC5017514

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