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Article

Genetic study between SIRT1, PPARD, PGC-1alpha genes and Alzheimer's disease.

Journal of neurology - 1 May 2008

Helisalmi S, Vepsäläinen S, Hiltunen M, Koivisto A M, Salminen A, Laakso M, Soininen H

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in three diabetes-related genes (SIRT1, PPARD, PGC-1alpha) were investigated with a case-control approach. To examine the genetic association of those genes with Alzheimer's disease (AD) risk, we used the TaqMan technique to genotype five SNP sites for SIRT1, six for PPARD and eight for the PGC-1alpha gene, in 326 Finnish AD cases and 463 controls and conducted a single...

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Source

Identifiers

PMID: 18438697
DOI: 10.1007/s00415-008-0774-1

Genes

SIRT1
PGC
PPARD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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