Article
The SIRT2 polymorphism rs10410544 and risk of Alzheimer's disease in two Caucasian case-control cohorts.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2013
Polito Letizia, Kehoe Patrick G, Davin Annalisa, Benussi Luisa, Ghidoni Roberta, Binetti Giuliano, Quadri Pierluigi, Lucca Ugo, Tettamanti Mauro, Clerici Francesca, Bagnoli Silvia, Galimberti Daniela, Nacmias Benedetta, Sorbi Sandro, Guaita Antonio, Scarpini Elio, Mariani Claudio, Forloni Gianluigi, Albani Diego
Abstract excerpt
BACKGROUND: Human sirtuins are a current hotspot for research in neurodegenerative disorders, including Alzheimer's disease (AD). This study investigated whether genetic variants in two members of the sirtuin family, SIRT2 and SIRT3, affected AD susceptibility. METHODS: A genetic case-control study was performed, comprising 534 probable AD cases and 638 nondemented control subjects from the north of Italy and...
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