Article
Genetic association of sirtuin genes and Parkinson's disease.
Journal of neurology - 1 Sept 2013
Jesús Silvia, Gómez-Garre Pilar, Carrillo Fátima, Cáceres-Redondo María T, Huertas-Fernández Ismael, Bernal-Bernal Inmaculada, Bonilla-Toribio Marta, Vargas-González Laura, Carballo Manuel, Mir Pablo
Abstract excerpt
Parkinson's disease (PD) is a neurodegenerative disease caused by both genetic and environmental factors. Sirtuins are highly-conserved, NAD-dependent class III deacetylases that regulate a variety of cellular functions. Most of the known sirtuins have been involved in animal models of neurodegen...
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