Article
SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin.
Free radical biology & medicine - 15 Mar 2009
Zillikens M Carola, van Meurs Joyce B J, Sijbrands Eric J G, Rivadeneira Fernando, Dehghan Abbas, van Leeuwen Johannes P T M, Hofman Albert, van Duijn Cornelia M, Witteman Jacqueline C M, Uitterlinden André G, Pols Huibert A P
Abstract excerpt
SIRT1 protects cells against oxidative stress and aging. Its activity may be modulated by dietary niacin (vitamin B3) intake. We studied the association of SIRT1 genetic variation with mortality in subjects with increased oxidative stress (type 2 diabetes and smokers) in relation to dietary niacin. In 4573 participants from the Rotterdam Study, including 413 subjects with prevalent and 378 with incident type 2...
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