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Article

The interactive effect of SIRT1 promoter region polymorphism on type 2 diabetes susceptibility in the North Indian population.

PloS one - 1 Jan 2012

Rai Ekta, Sharma Swarkar, Kaul Surabhi, Jain Kamal, Matharoo Kawaljit, Bhanwer Amarjit S, Bamezai Rameshwar N K

Abstract excerpt

Our previous studies have implicated genes mainly involved in the activity of pancreatic β cells in type 2 diabetes (T2D) susceptibility in the North Indian population. Recent literature on the role of SIRT1 as a potential master switch modulating insulin secretion and regulating gene expression in pancreatic β cells has warranted an evaluation of SIRT1 promoter region polymorphisms in the North Indian...

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Topics

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Share to Diabetes Mellitus, Type 2
Share to Genetic Markers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin Resistance

Share to Odds Ratio

Share to Promoter Regions, Genetic

Share to Sirtuin 1

Source

Open in PubMed Open full text

Identifiers

PMID: 23133645
DOI: 10.1371/journal.pone.0048621
PMCID: PMC3486794

Genes

SIRT1
IRS1
UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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