Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Type 2 diabetes-associated polymorphisms correlate with SIRT1 and TGF-β1 gene expression.

Annals of human genetics - 1 Mar 2020

Ramírez Ángeles, Hernández Miriam, Suárez-Sánchez Rocío, Ortega Clara, Peralta Jesús, Gómez Jaime, Valladares Adán, Cruz Miguel, Vázquez-Moreno Miguel Alexander, Suárez-Sánchez Fernando

Abstract excerpt

The polymorphisms rs3758391 and rs1800470 located in SIRT1 and TGF-β1 have been associated with type 2 diabetes in different populations but its functional effect is not clear. In this study, we evaluated their effect on the expression of SIRT1 and TGF-β1 in peripheral blood as well as their participation in the formation of DNA-protein complexes in a pancreas-derived cell line. It has been described that SIRT1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomarkers
Share to Diabetes Mellitus, Type 2
Share to Genetic Predisposition to Disease
Share to Linkage Disequilibrium
Share to Polymorphism, Single Nucleotide
Share to Prognosis
Share to Sirtuin 1
Share to Transforming Growth Factor beta1

Source

Identifiers

PMID: 31799723
DOI: 10.1111/ahg.12363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Type 2 diabetes-associated polymorphisms correlate with SIRT1 and TGF-β1 gene expression.PMID 31799723Read ↗

Study on Expression of Gene Encoding Sirtuin-1 and Its Association with Single Nucleotide Polymorphism in Type 2 Diabetes MellitusSemantic proximity Read ↗

The interactive effect of SIRT1 promoter region polymorphism on type 2 diabetes susceptibility in the North Indian population.Semantic proximity Read ↗

Common Genetic Variants in SIRT1 Gene Promoter and Type 2 Diabetes Mellitus in Saudi Arabia.Semantic proximity Read ↗

Sirtuin 1 gene polymorphisms are associated with body fat and blood pressure in Japanese.Semantic proximity Read ↗

TGF-β1 functional polymorphisms: a review.Semantic proximity Read ↗

Haplotypes of the Mutated SIRT2 Promoter Contributing to Transcription Factor Binding and Type 2 Diabetes Susceptibility.Semantic proximity Read ↗

Association of SIRT1 rs3758391 Polymorphism With T2DM in Bangladeshi Population: Evidence From a Case‐Control Study and Meta‐AnalysisSemantic proximity Read ↗

Understanding Genetic Heterogeneity in Type 2 Diabetes by Delineating Physiological Phenotypes: SIRT1 and its Gene Network in Impaired Insulin Secretion.Semantic proximity Read ↗

Functional genetic variants within the SIRT2 gene promoter in type 2 diabetes mellitus.Semantic proximity Read ↗

Correlation Between Polymorphisms of the SIRT1 Gene microRNA Target Sites and Diabetic Nephropathy.Semantic proximity Read ↗

Association of Genetic Variants of SIRT1 With Type 2 Diabetes Mellitus.Semantic proximity Read ↗

SIRT1 functional polymorphisms (rs12778366, rs3758391) as genetic biomarkers of susceptibility to type 2 diabetes mellitus in Iranians: a case-control study and computational analysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.