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Article

Exploiting genetic diversity by directed evolution: molecular breeding of type III polyketide synthases improves productivity.

Molecular bioSystems - 1 Mar 2008

Zha Wenjuan, Rubin-Pitel Sheryl B, Zhao Huimin

Abstract excerpt

Applying directed evolution to the phloroglucinol synthase PhlD from Pseudomonas fluorescens Pf-5 has provided the first example of engineering enhanced productivity in a type III polyketide synthase, and a rare instance of improving the activity of a biosynthetic enzyme from secondary metabolism.

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PMID: 18437267
DOI: 10.1039/b717705d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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