Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Widening the pH activity profile of a fungal laccase by directed evolution.

Chembiochem : a European journal of chemical biology - 27 May 2013

Torres-Salas Pamela, Mate Diana M, Ghazi Iraj, Plou Francisco J, Ballesteros Antonio O, Alcalde Miguel

Abstract excerpt

Unnatural selection: A fungal laccase was tailored by directed evolution to be active at neutral/alkaline pH. After five generations, the final mutant showed a broader pH profile while retaining 50 to 80 % of its activity at neutral pH.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Directed Molecular Evolution
Share to Hydrogen-Ion Concentration
Share to Laccase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Mutation

Share to Saccharomyces cerevisiae

Share to Substrate Specificity

Source

Identifiers

PMID: 23592228
DOI: 10.1002/cbic.201300102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Widening the pH activity profile of a fungal laccase by directed evolution.PMID 23592228Read ↗

Evolving stability and pH-dependent activity of the high redox potential Botrytis aclada laccase for enzymatic fuel cells.Semantic proximity Read ↗

Blood tolerant laccase by directed evolution.Semantic proximity Read ↗

Improving the decolorization for textile dyes of a metagenome-derived alkaline laccase by directed evolution.Semantic proximity Read ↗

Direct evolution of an alkaline fungal laccase to degrade tetracyclines.Semantic proximity Read ↗

Engineering platforms for directed evolution of Laccase from Pycnoporus cinnabarinus.Semantic proximity Read ↗

Colorimetric High-Throughput Screening Assays for the Directed Evolution of Fungal Laccases.Semantic proximity Read ↗

Modulating the pH-activity profile of cellulase A from Cellulomonas fimi by replacement of surface residues.Semantic proximity Read ↗

In vitro evolution of a fungal laccase in high concentrations of organic cosolvents.Semantic proximity Read ↗

Enhanced catalytic performance and pH stability of Streptomyces Laccase Y230R and its degradation of malachite green.Semantic proximity Read ↗

Advances in laboratory evolution of enzymes.Semantic proximity Read ↗

Characterization of a thermostable mutant of Agaricus brasiliensis laccase created by phylogeny-based design.Semantic proximity Read ↗

Directed evolution: selecting today's biocatalysts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.