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Article

The effect of genetic polymorphisms of AKT1 on PE susceptibility: a case-control study and insilico analysis.

Personalized medicine - 1 Feb 2025

Rezaei Mahnaz, Ghasemi Marzieh, Saravani Mohsen, Shahraki-Ghadimi Hossein, Ghasemian Moghadam Rahele, Salimi Saeedeh

Abstract excerpt

BACKGROUND: Preeclampsia (PE) is a gestational disease associated with developing hypertension and proteinuria. AIM: This study investigated the effects of AKT1 polymorphisms, a key enzyme in cellular signal transmission that regulates various cellular processes associated with PE. METHODS: The PCR-RFLP method was employed to genotype AKT1 rs2494732, rs1130233, and rs1130214 polymorphisms. In silico analysis was...

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Source

Identifiers

PMID: 39960165
DOI: 10.1080/17410541.2024.2446006

Genes

AKT1

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