Article
Analysis of LRRK 2 G 2019 S and I 2020 T mutations in Parkinson's disease.
Neuroscience letters - 16 Dec 2005
Bialecka Monika, Hui Shen, Klodowska-Duda Gabriela, Opala Grzegorz, Tan Eng-King, Drozdzik Marek
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK 2), encoding dardarin protein, have been demonstrated to be linked to autosomal dominant Parkinson's disease (PD). In the present study the entire exon 41 of LRRK 2 gene was evaluated in a series of 174 PD patients recruited from Polish populati...
Topics
- Aged
- Biomarkers
- DNA Mutational Analysis
- Female
- Genetic Predisposition to Disease
- Genetic Testing
- Humans
- Incidence
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged
- Mutation
- Parkinson Disease
- Poland
- Polymorphism, Genetic
- Protein Serine-Threonine Kinases
- Risk Assessment
- Risk Factors