Article
A common leucine-rich repeat kinase 2 gene mutation in familial and sporadic Parkinson's disease in Russia.
European journal of neurology - 1 Apr 2007
Illarioshkin S N, Shadrina M I, Slominsky P A, Bespalova E V, Zagorovskaya T B, Bagyeva G Kh, Markova E D, Limborska S A, Ivanova-Smolenskaya I A
Abstract excerpt
A PARK8 form of Parkinson's disease (PD) is caused by a novel gene, leucine-rich repeat kinase 2 (LRRK2), and a single mutation G2019S was found in a proportion of LRRK2-associated cases of diverse ethnic origins. We performed the LRRK2 G2019S mutation analysis in 304 Russian patients with PD, including 291 sporadic and 13 autosomal dominant cases. The frequency of the LRRK2 G2019S was 0.7% amongst the sporadic...
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