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Article

The roles of cys124 and ser239 in the functional properties of human βIII tubulin

24 Apr 2008

Abstract excerpt

Tubulin is the target for some very powerful anti-mitotic and anti-tumor drugs. The betaIII tubulin isotype is found in very few normal tissues, but is often found in tumors, where it has been implicated in resistance to anti-tumor drugs. The betaIII isotype occurs in fish, amphibians, birds and mammals and its unique features are highly conserved in evolution. One of these features is the replacement of cys239...

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PMID: 18435451
DOI: 10.1002/cm.20274

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