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Article

2-(m-Azidobenzoyl)taxol binds differentially to distinct β-tubulin isotypes.

Proceedings of the National Academy of Sciences of the United States of America - 4 Oct 2016

Yang Chia-Ping Huang, Yap Eng-Hui, Xiao Hui, Fiser Andras, Horwitz Susan Band

Abstract excerpt

There are seven β-tubulin isotypes present in distinct quantities in mammalian cells of different origin. Altered expression of β-tubulin isotypes has been reported in cancer cell lines resistant to microtubule stabilizing agents (MSAs) and in human tumors resistant to Taxol. To study the relative binding affinities of MSAs, tubulin from different sources, with distinct β-tubulin isotype content, were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27651486
DOI: 10.1073/pnas.1613286113
PMCID: PMC5056068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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