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Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives

1 Nov 2018

Abstract excerpt

Microtubules are tubulin polymer structures, which are indispensable for cell growth and division. Its constituent protein β-tubulin has been a common drug target for various diseases including cancer. Colchicine has been used to treat gout, but it has also been an investigational anticancer agent with a known antimitotic effect on cells. However, the use of colchicine as well as many of its derivatives in...

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PMID: 30388878
DOI: 10.3390/cells7110192

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