Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ancestral roles of eukaryotic frataxin: mitochondrial frataxin function and heterologous expression of hydrogenosomal Trichomonas homologues in trypanosomes.

Molecular microbiology - 1 Jul 2008

Long Shaojun, Jirků Milan, Mach Jan, Ginger Michael L, Sutak Robert, Richardson Des, Tachezy Jan, Lukes Julius

Abstract excerpt

Frataxin is a small conserved mitochondrial protein; in humans, mutations affecting frataxin expression or function result in Friedreich's ataxia. Much of the current understanding of frataxin function comes from informative studies with yeast models, but considerable debates remain with regard t...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eukaryotic Cells
Share to Frataxin
Share to Iron-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Iron-Sulfur Proteins

Share to Mitochondrial Proteins

Share to Prokaryotic Cells

Share to Protozoan Proteins

Share to RNA Interference

Source

Identifiers

PMID: 18433447
DOI: 10.1111/j.1365-2958.2008.06260.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18433447-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ancestral roles of eukaryotic frataxin: mitochondrial frataxin function and heterologous expression of hydrogenosomal Trichomonas homologues in trypanosomes.PMID 18433447Read ↗

Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity.Semantic proximity Read ↗

Reduction in frataxin causes progressive accumulation of mitochondrial damage.Semantic proximity Read ↗

Iron metabolism and mitochondrial abnormalities in Friedreich ataxia.Semantic proximity Read ↗

Recent advances in the molecular pathogenesis of Friedreich ataxia.Semantic proximity Read ↗

Differential contribution of two organelles of endosymbiotic origin to iron-sulfur cluster synthesis and overall fitness in ToxoplasmaSemantic proximity Read ↗

Frataxin: a protein in search for a function.Semantic proximity Read ↗

Iron metabolism in trypanosomatids, and its crucial role in infectionSemantic proximity Read ↗

Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells.Semantic proximity Read ↗

The mitochondrial protein frataxin prevents nuclear damage.Semantic proximity Read ↗

The vacuolar iron transporter mediates iron detoxification in Toxoplasma gondiiSemantic proximity Read ↗

Cells lacking pfh1, a fission yeast homolog of mammalian frataxin protein, display constitutive activation of the iron starvation response.Semantic proximity Read ↗

Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viabilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.