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Iron metabolism in trypanosomatids, and its crucial role in infection

15 Feb 2010

Abstract excerpt

Iron is almost ubiquitous in living organisms due to the utility of its redox chemistry. It is also dangerous as it can catalyse the formation of reactive free radicals - a classical double-edged sword. In this review, we examine the uptake and usage of iron by trypanosomatids and discuss how modulation of host iron metabolism plays an important role in the protective response. Trypanosomatids require iron for...

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PMID: 20152063
DOI: 10.1017/s0031182009991880

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