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Article

Frataxin: a protein in search for a function.

Journal of neurochemistry - 1 Aug 2013

Pastore Annalisa, Puccio Helene

Abstract excerpt

Reduced levels of the protein frataxin cause the neurodegenerative disease Friedreich's ataxia. Pathology is associated with disruption of iron-sulfur cluster biosynthesis, mitochondrial iron overload, and oxidative stress. Frataxin is a highly conserved iron-binding protein present in most organisms. Despite the intense interest generated since the determination of its pathology, identification of the cellular...

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Identifiers

PMID: 23859340
DOI: 10.1111/jnc.12220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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