Article

Differential contribution of two organelles of endosymbiotic origin to iron-sulfur cluster synthesis and overall fitness in Toxoplasma

2021-01-28

Abstract excerpt

Iron-sulfur (Fe-S) clusters are one of the most ancient and ubiquitous prosthetic groups, and they are required by a variety of proteins involved in important metabolic processes. Apicomplexan parasites have inherited different plastidic and mitochondrial Fe-S clusters biosynthesis pathways through endosymbiosis. We have investigated the relative contributions of these pathways to the fitness of Toxoplasma gondii...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d533c11f-f371-5a4d-af72-3097be23286b
DOI: 10.1101/2021.01.28.428257

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Differential contribution of two organelles of endosymbiotic origin to iron-sulfur cluster synthesis and overall fitness in ToxoplasmaDOI 10.1101/2021.01.28.428257Read

Differential contribution of two organelles of endosymbiotic origin to iron-sulfur cluster synthesis and overall fitness in ToxoplasmaSemantic proximity Read

Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viabilitySemantic proximity Read

The Plasmodium falciparum apicoplast cysteine desulfurase provides sulfur for both iron sulfur cluster assembly and tRNA modificationSemantic proximity Read

Parasite powerhouse: A review of the Toxoplasma gondii mitochondrionSemantic proximity Read

A mutagenesis screen for essential plastid biogenesis genes in human malaria parasitesSemantic proximity Read

The apicoplast is important for the viability and persistence of Toxoplasma gondii bradyzoitesSemantic proximity Read

A mutagenesis screen for essential plastid biogenesis genes in human malaria parasitesSemantic proximity Read

The vacuolar iron transporter mediates iron detoxification in Toxoplasma gondiiSemantic proximity Read

Two essential Thioredoxins mediate apicoplast biogenesis, protein import, and gene expression in Toxoplasma gondii.Semantic proximity Read

In vivo CRISPR screens identify novel virulence genes among proteins of unassigned subcellular localization in ToxoplasmaSemantic proximity Read

Toxoplasma TgAtg8-TgAtg3 Interaction Primarily Contributes to Apicoplast Inheritance and Parasite Growth in Tachyzoite.Semantic proximity Read

Mitochondrion-Related Organelles in Eukaryotic ProtistsSemantic proximity Read