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Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells.

Human molecular genetics - 15 Dec 2005

Schoenfeld Robert A, Napoli Eleonora, Wong Alice, Zhan Shan, Reutenauer Laurence, Morin Dexter, Buckpitt Alan R, Taroni Franco, Lonnerdal Bo, Ristow Michael, Puccio Hélène, Cortopassi Gino A

Abstract excerpt

Deficiency of the frataxin mRNA alters the transcriptome, triggering neuro- and cardiodegeneration in Friedreich's ataxia. We microarrayed murine frataxin-deficient heart tissue, liver tissue and cardiocytes and observed a transcript down-regulation to up-regulation ratio of nearly 2:1 with a mit...

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PMID: 16239244
DOI: 10.1093/hmg/ddi393

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CPOX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16239244-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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