Article
Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice.
Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 2008
Holstege Jan C, de Graaff Wim, Hossaini Mehdi, Cardona Cano Sebastian, Jaarsma Dick, van den Akker Eric, Deschamps Jacqueline
Abstract excerpt
Although Hox gene expression has been linked to motoneuron identity, a role of these genes in development of the spinal sensory system remained undocumented. Hoxb genes are expressed at high levels in the dorsal horn of the spinal cord. Hoxb8 null mutants manifest a striking phenotype of excessive grooming and hairless lesions on the lower back. Applying local anesthesia underneath the hairless skin suppressed...
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