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Article

Estrogen receptor beta is essential for sprouting of nociceptive primary afferents and for morphogenesis and maintenance of the dorsal horn interneurons.

Proceedings of the National Academy of Sciences of the United States of America - 21 Aug 2007

Fan Xiaotang, Kim Hyun-Jin, Warner Margaret, Gustafsson Jan-Ake

Abstract excerpt

Estrogen is known to influence pain, but the specific roles of the two estrogen receptors (ERs) in the spinal cord are unknown. In the present study, we have examined the expression of ERalpha and ERbeta in the spinal cord and have looked for defects in pain pathways in ERbeta knockout (ERbeta(-/-)) mice. In the spinal cords of 10-month-old WT mice, ERbeta-positive cells were localized in lamina II, whereas...

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Identifiers

PMID: 17693550
DOI: 10.1073/pnas.0705936104
PMCID: PMC1959444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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