Article
DRG11 immunohistochemical expression during embryonic development in the mouse.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Sept 2007
Rebelo Sandra, Reguenga Carlos, Osório Liliana, Pereira Carlos, Lopes Claúdia, Lima Deolinda
Abstract excerpt
DRG11 is a paired domain transcription factor that is necessary for the assembly of the nociceptive circuitry in the spinal cord dorsal horn. It is expressed in small dorsal root ganglion (DRG) neurons and in their projection area in the spinal cord. Drg11 knockout mice exhibit structural and neurochemical defects both at the DRG and spinal superficial dorsal horn and present reduced nociceptive responses. In...
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