Article
Mice lacking spinal α2GABAA receptors: Altered GABAergic neurotransmission, diminished GABAergic antihyperalgesia, and potential compensatory mechanisms preventing a hyperalgesic phenotype.
Brain research - 15 Aug 2020
Tudeau Laetitia, Acuña Mario A, Albisetti Gioele W, Neumann Elena, Ralvenius William T, Scheurer Louis, Poe Michael, Cook James M, Johannssen Helge C, Zeilhofer Hanns Ulrich
Abstract excerpt
Diminished synaptic inhibition in the superficial spinal dorsal horn contributes to exaggerated pain responses that accompany peripheral inflammation and neuropathy. α2GABAA receptors (α2GABAAR) constitute the most abundant GABAAR subtype at this site and are the targets of recently identified antihyperalgesic compounds. Surprisingly, hoxb8-α2-/- mice that lack α2GABAAR from the spinal cord and peripheral sensory...
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