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Active Rab11 and functional recycling endosome are required for E-cadherin trafficking and lumen formation during epithelial morphogenesis.

American journal of physiology. Cell physiology - 1 Aug 2008

Desclozeaux Marion, Venturato Juliana, Wylie Fiona G, Kay Jason G, Joseph Shannon R, Le Huong T, Stow Jennifer L

Abstract excerpt

The correct targeting and trafficking of the adherens junction protein epithelial cadherin (E-cadherin) is a major determinant for the acquisition of epithelial cell polarity and for the maintenance of epithelial integrity. The compartments and trafficking components required to sort and transport E-cadherin to the basolateral cell surface remain to be fully defined. On the basis of previous data, we know that...

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PMID: 18579802
DOI: 10.1152/ajpcell.00097.2008

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